No that's a big difference, the fuel in the main tank is mid range pump gas E-10 (89 AKI) the fuel in the portable tank is E-0 94 octane and was fresh, just bought it in Sept when I was doing the tests. Only one gas station around here sells it, and it's like $7.50 a gallon, I wanted to try it in the boat because I had good results with it in my yard engines. Since the boat ran bad from when I launched it, I never used up the fuel in the tank, which is now about 15 months old but was stabilized when new.
Now every year at the start of the season, I have always topped the boat off with fuel I stored for the generator, that at that time is maybe 6 months old but was stabilized when I bought it and all these years I have never had a problem like this. During the season when the boat's on the mooring, it gets fueled with 93 octane marine fuel because that's all the gas docks here sell.
BTW since OMC I/Os have not been sold for many years, just for the heck of it I went on BRP's website and looked up the last Evinrude (Etec) and Johnson (4 stroke) manuals to see what fuel is recommended, for both, it's 87 AKI.
As far as timing, I have always used 6*BTDC, and I checked the total timing advance as well, which as you probably know it much lower on the 4.3 V6 than it is for the V8s, it only gets 12* of centrifugal advance at 3200 rpm, so your total timing advance is only 18*.